Effective Supplement of Vitamin C Reduces Oxidative Stress

Can you eat enough fruit to be an effective antioxidant?

Can Vitamin C reduce Oxidative Stress?  Vitamin C has antioxidant properties, which means that it reacts with reactive oxygen species (ROS) to neutralize it.  There are reports of Vitamin C being an ineffective antioxidant supplement.  However, a mismatch of the supplement format compared to the source of Oxidative Stress may be the cause.  Supplements come in three main formats, which provide the release of the compounds immediate, time, or sustained release.

Immediate Release

The immediate release is usually a tablet format or chewable.  This format provides a near instantaneous increase in the concentration of the compound in the blood.  This assumes implied losses due to stomach digestion and absorption prior to entry into the blood stream.


With time-release, the format prevents rapid capsule digestion in the stomach with release in the small intestine.  Time-release is not immediate, but it does avoid losses due to stomach digestion.  Both immediate and time-release formats provide a short-term spike in compound concentration in the bloodstream.


With sustained-release, the capsule releases the compounds over several hours, which will provide a steady, low concentration of the compound(s) in the blood stream. Which supplement format is the best for antioxidant effectiveness?

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