Oxidative Stress is the elevated concentration of reactive oxygen species (ROS) in tissue. Blood Oxidative Stress or BLOS is the primary source of Oxidative Stress. BLOS is ROS-positive white blood cells and platelets. It is thought that the high amounts of inorganic sulfur compounds used as food additives may be the dietary cause of BLOS. Oxidative Stress may be an Asymptomatic Disease responsible for multiple health problems including Obesity, Hypertension, Cardiovascular Disease, and a greater risk of Cancer.
The Right To Try Bill is a new Law, which offers hope for terminally ill patients interested in trying experimental drugs that passed Phase 1 safety standards from the FDA. While encouraging, the grim reality of experimental drugs is that a large majority fail in Phase 2/3 of Clinical Trials. This is despite Pre-Clinical experiments providing evidence that these experimental drugs work in animal models. Could variable levels of Oxidative Stress in humans cause some of this failure? If true, then there may be a simple way to improve the odds of an experimental drug working for Right To Try patients. This approach should also interest Big Pharma. An Oxidative Stress Test provides feedback on lifestyle choices for lowering Oxidative Stress. This approach should be used prior to using experimental drugs for better results.
Elevated Blood Oxidative Stress May Impact Clinical Trials
The primary source of Oxidative Stress in adult Americans is from blood cells, which we call Blood Oxidative Stress or BLOS. Although about 2/3 of adult Americans are thought to suffer from elevated levels of BLOS, medical researchers do NOT control it during Clinical Trials. Control in this context means minimizing BLOS during the clinical trial. But Big Pharma has been doing this for decades and this is the right approach for evaluating experimental drugs, right?
Probiotics are found in supplements and food items with the promise of a health benefit. However, the FDA has yet to approve any probiotic for the treatment of any human disease. While animal studies provide evidence that probiotics may be an effective treatment for health problems, human studies always come up short. There may be a simple explanation for this observation: Oxidative Stress. Learn how to enhance probiotics for women and men by reducing and managing Oxidative Stress.
The answers to these questions and more are in my new eBook, “Let’s Hack Oxidative Stress.” In my eBook, I provide a simple strategy for using three lifestyle choices to reduce your Oxidative Stress and improve your health. You need to measure your Oxidative Stress with a Urine Test Kit to monitor the progress of your Hack. The rest of the items needed for your Hack should be available at local stores, but there is a simpler way to gather up all of the products for your Hack: Buy an Oxidative Stress Hack Kit from my Store!
Find All of Your BLOS Hack Kit Products Here
In addition to my eBook, I identified several high quality products for your Hack. I have already done the shopping for you! There are Oxidative Stress Hack Kits for either gender in both Deluxe and Basic formats. The Lite Oxidative Stress Hack Kit is for the health-conscious person that already has most of the items needed for the Hack. Get your life back on track by getting a handle on Oxidative Stress.
Can Vitamin C reduce Oxidative Stress? Vitamin C has antioxidant properties, which means that it reacts with reactive oxygen species (ROS) to neutralize it. There are reports of Vitamin C being an ineffective antioxidant supplement. However, a mismatch of the supplement format compared to the source of Oxidative Stress may be the cause. Supplements come in three main formats, which provide the release of the compounds immediate, time, or sustained release.
The immediaterelease is usually a tablet format or chewable. This format provides a near instantaneous increase in the concentration of the compound in the blood. This assumes implied losses due to stomach digestion and absorption prior to entry into the blood stream.
With time-release, the format prevents rapid capsule digestion in the stomach with release in the small intestine. Time-release is not immediate, but it does avoid losses due to stomach digestion. Both immediate and time-release formats provide a short-term spike in compound concentration in the bloodstream.
With sustained-release, the capsule releases the compounds over several hours, which will provide a steady, low concentration of the compound(s) in the blood stream. Which supplement format is the best for antioxidant effectiveness?
If Blood Oxidative Stress or BLOS impacts your pet’s health, then an antioxidant supplement may help reduce BLOS and improve your pet’s health. BLOS has been suggested as a cause of Obesity and Diabetes, since it can inhibit glucose transport and fat metabolism. There is a growing problem of obesity and diabetes in our pets. Are we feeding our pets too much or is it something in the food causing BLOS? Here is s an in-depth guide to the problem of obesity in dogs. Beyond pet food, we may be able help our pets by providing an effective antioxidant supplement. Could antioxidant supplements consisting of effective antioxidants and designed for time-release help your pet? We reviewed the scientific research and provided a short list of the Best Antioxidant Supplements for your Pet.
Oxidative Stress is the major healthcare problem plaguing the United States, Europe, and other countries that adopted the Western Diet. The major source of Oxidative Stress is from the blood, which presents major problems for management or prevention to improve health. First, Blood Oxidative Stress or BLOS cannot be measured due to the lack of a proper method. Second, BLOS is continuous (24/7), while General Oxidative Stress is temporary. High, variable levels of Oxidative Stress depletes your body’s own antioxidants, whether from diet or the body. Poor fitness in adult Americans also contributes to poor BLOS management due to minimal endogenous antioxidant production. Endogenous means that your own body makes it. Oxidative Stress prevention could be the key to improving health.
What is Oxidative Stress? Let’s review the two sources of Oxidative Stress and determine which source is more important. General Oxidative Stress is thought to be the only source of Oxidative Stress. However, Blood can also generate Oxidative Stress, which is also known as BLOS. This post provides information about why BLOS is more important compared to General Oxidative Stress. EBooks (and Books) and BLOS Health Hack Kits may help you fight BLOS for better health.
General Oxidative Stress
The mechanistic model of General Oxidative Stress starts with an elevated rate of metabolism that results in mitochondrial dysfunction. In turn, this leads to an increased production of reactive oxygen species (ROS). Medical researchers observe General Oxidative Stress in tissue cultures, but it is difficult to observe in the human body. How many biopsies are needed to identify the tissues sources of General Oxidative Stress? Instead, medical researchers rely on diagnostic methods that evaluate ROS or oxidation end products in blood, urine, or breath.
Excessive alcohol consumption is a special case of General Oxidative Stress. It causes short periods of ROS generation in the liver and other organs. Short periods of ROS generation is a primary characteristic of General Oxidative Stress. It is due to the reliance on excessive substrate availability necessary for the elevated rate of metabolism. A second source of Oxidative Stress is from blood cells, which received little attention from medical researchers or the general public.
Blood Oxidative Stress
White blood cells and platelets can generate high rates of ROS, which is alarming when the patient does not have an infection. In 2008, Walter Paulus’ research group reported on ROS+ blood cells in both healthy (non-hospitalized) and congestive heart failure (CHF) patients. Here is the link for the Abstract of the research article describing Blood Oxidative Stress or BLOS: https://www.ncbi.nlm.nih.gov/pubmed/18957960 This article provides interesting BLOS data and I will focus on the most important findings, which escaped the attention of the researchers. The research community missed it, but this is understandable when you consider that there are over 200,000 research articles about Oxidative Stress. The Paulus’ paper is the proverbial “needle in the haystack” for Oxidative Stress.
Hypertension is one of many health problems associated with Oxidative Stress. In the fight against Oxidative Stress, improved fitness often takes the backseat to dietary changes. Some folks think that a regimen of low-dose aspirin will reduce their risk of heart attack or stroke. Recent research suggests that this idea is wrong. The idea of exercise is dreadful for most people, especially as they get older and life gets more complicated. This post provides information on a simple fitness tip that reduces Hypertension. Always consult with your physician before making any changes in your exercise routine and diet (read our Disclaimer below).