BLOS is blood oxidative stress, which is the predominant source of Oxidative Stress in humans. Currently, more than 2/3 of adult Americans are thought to suffer from elevated BLOS, so there’s interest in learning more about methods for managing it.
The Right To Try Bill is a new Law, which offers hope for terminally ill patients interested in trying experimental drugs that passed Phase 1 safety standards from the FDA. While encouraging, the grim reality of experimental drugs is that a large majority fail in Phase 2/3 of Clinical Trials. This is despite Pre-Clinical experiments providing evidence that these experimental drugs work in animal models. Could variable levels of Oxidative Stress in humans cause some of this failure? If true, then there may be a simple way to improve the odds of an experimental drug working for Right To Try patients. This approach should also interest Big Pharma. An Oxidative Stress Test provides feedback on lifestyle choices for lowering Oxidative Stress. This approach should be used prior to using experimental drugs for better results.
Elevated Blood Oxidative Stress May Impact Clinical Trials
The primary source of Oxidative Stress in adult Americans is from blood cells, which we call Blood Oxidative Stress or BLOS. Although about 2/3 of adult Americans are thought to suffer from elevated levels of BLOS, medical researchers do NOT control it during Clinical Trials. Control in this context means minimizing BLOS during the clinical trial. But Big Pharma has been doing this for decades and this is the right approach for evaluating experimental drugs, right?
The answers to these questions and more are in my new eBook, “Let’s Hack Oxidative Stress.” In my eBook, I provide a simple strategy for using three lifestyle choices to reduce your Oxidative Stress and improve your health. You need to measure your Oxidative Stress with a Urine Test Kit to monitor the progress of your Hack. The rest of the items needed for your Hack should be available at local stores, but there is a simpler way to gather up all of the products for your Hack: Buy an Oxidative Stress Hack Kit from my Store!
Find All of Your BLOS Hack Kit Products Here
In addition to my eBook, I identified several high quality products for your Hack. I have already done the shopping for you! There are Oxidative Stress Hack Kits for either gender in both Deluxe and Basic formats. The Lite Oxidative Stress Hack Kit is for the health-conscious person that already has most of the items needed for the Hack. Get your life back on track by getting a handle on Oxidative Stress.
Oxidative Stress is the major healthcare problem plaguing the United States, Europe, and other countries that adopted the Western Diet. The major source of Oxidative Stress is from the blood, which presents major problems for management or prevention to improve health. First, Blood Oxidative Stress or BLOS cannot be measured due to the lack of a proper method. Second, BLOS is continuous (24/7), while General Oxidative Stress is temporary. High, variable levels of Oxidative Stress depletes your body’s own antioxidants, whether from diet or the body. Poor fitness in adult Americans also contributes to poor BLOS management due to minimal endogenous antioxidant production. Endogenous means that your own body makes it. Oxidative Stress prevention could be the key to improving health.
The signs of oxidative stress from blood take years to fully develop, but early diagnosis may prevent many health problems. The traditional approach to disease diagnosis is through the observation of one or more symptoms. Rapid, accurate diagnosis is the key to treating symptomatic diseases. Diseases that take years or decades to manifest as symptoms are Asymptomatic and rely on the underlying pathology for diagnosis. Two examples of Asymptomatic Diseases are Alzheimer’s and Cardiovascular Diseases. A recent news article describes how the Research Community redefined Alzheimer’s Disease as an Asymptomatic Disease. In turn, this new definition will lead the development of new drugs for treating the underlying pathology before symptoms develop. Blood Oxidative Stress or BLOS is another Asymptomatic Disease that demands more attention from the medical research community and public health officials.
Blood Oxidative Stress (BLOS)
Oxidative Stress receives lots of attention from medical researchers with new theories suggesting it causes multiple health problems including an increased risk of cancer. There at least two sources of Oxidative Stress and Blood Oxidative Stress or BLOS may be the dominant source. BLOS may be the true underlying cause of several diseases. In fact, the underlying cause of Cardiovascular Disease may be BLOS, since it provides a mechanistic model for atherosclerosis that does not depend on a genetic mutation.
What is Oxidative Stress? Let’s review the two sources of Oxidative Stress and determine which source is more important. General Oxidative Stress is thought to be the only source of Oxidative Stress. However, Blood can also generate Oxidative Stress, which is also known as BLOS. This post provides information about why BLOS is more important compared to General Oxidative Stress. EBooks (and Books) and BLOS Health Hack Kits may help you fight BLOS for better health.
General Oxidative Stress
The mechanistic model of General Oxidative Stress starts with an elevated rate of metabolism that results in mitochondrial dysfunction. In turn, this leads to an increased production of reactive oxygen species (ROS). Medical researchers observe General Oxidative Stress in tissue cultures, but it is difficult to observe in the human body. How many biopsies are needed to identify the tissues sources of General Oxidative Stress? Instead, medical researchers rely on diagnostic methods that evaluate ROS or oxidation end products in blood, urine, or breath.
Excessive alcohol consumption is a special case of General Oxidative Stress. It causes short periods of ROS generation in the liver and other organs. Short periods of ROS generation is a primary characteristic of General Oxidative Stress. It is due to the reliance on excessive substrate availability necessary for the elevated rate of metabolism. A second source of Oxidative Stress is from blood cells, which received little attention from medical researchers or the general public.
Blood Oxidative Stress
White blood cells and platelets can generate high rates of ROS, which is alarming when the patient does not have an infection. In 2008, Walter Paulus’ research group reported on ROS+ blood cells in both healthy (non-hospitalized) and congestive heart failure (CHF) patients. Here is the link for the Abstract of the research article describing Blood Oxidative Stress or BLOS: https://www.ncbi.nlm.nih.gov/pubmed/18957960 This article provides interesting BLOS data and I will focus on the most important findings, which escaped the attention of the researchers. The research community missed it, but this is understandable when you consider that there are over 200,000 research articles about Oxidative Stress. The Paulus’ paper is the proverbial “needle in the haystack” for Oxidative Stress.
A review of the current medical research suggests that three Antioxidant Supplements may reduce Oxidative Stress for improved health.
The two reported sources of Oxidative Stress are General and Blood Oxidative Stress or BLOS. General Oxidative Stress is the more familiar due to its earlier discovery. However, BLOS is probably the primary cause of Oxidative Stress. General Oxidative Stress results from short periods of elevated metabolism rates within cells that generates reactive oxygen species (ROS). In contrast, BLOS is a large fraction of your blood cells induced to generate high levels of ROS. Long term, elevated BLOS is the probable cause of multiple health problems. More than 2/3 of adult Americans suffer from BLOS. Both sources of Oxidative Stress result in high levels of ROS that diffuse throughout the body causing damage and health problems. Although your body does produce low levels of antioxidant, excessive ROS may require an antioxidant supplement to manage Oxidative Stress.
Here is a list of the Top 5 Foods to avoid, if you want to reduce Oxidative Stress and improve your health. Avoiding ultra-processed foods may reduce your risk of cancer, but are they all bad for you? Many ultra-processed foods have one thing in common: high levels of inorganic sulfur. This type of sulfur leads to the growth of sulfate reducing bacteria (SRB) in your gut, which may cause your blood cells to generate high levels of reactive oxygen species (ROS), the primary source of Oxidative Stress. In the long term, high levels of ROS can damage DNA, which can cause cancer.
BLOS World provides a review of the best information and products to reduce Oxidative Stress. Why should you worry about Oxidative Stress? Start with learning more about Oxidative Stress generated by your blood.
What is Blood Oxidative Stress?
Blood Oxidative Stress (BLOS) is probably the primary cause of Oxidative Stress. In BLOS, activated blood cells generate high levels of reactive oxygen species (ROS). However, reducing the amount of inorganic sulfur in the diet and adding effective antioxidant supplements may manage BLOS. About 2/3 adult Americans are thought to suffer from elevated BLOS. BLOS extends beyond the USA with Europe and countries that adopted the Western Diet. The effective management of BLOS may be the key to treating several health problems including Obesity, Type 2 Diabetes, Hypertension, and the risk of Cancer. In the USA, BLOS is thought to be responsible for annual healthcare costs of more than $800B.