Oxidative Stress Blood Test Good for Patients and Pharma

How does Oxidative Stress Impact Clinical Trials?

The Right To Try Bill is a new Law, which offers hope for terminally ill patients interested in trying experimental drugs that passed Phase 1 safety standards from the FDA.  While encouraging, the grim reality of experimental drugs is that a large majority fail in Phase 2/3 of Clinical Trials.  This is despite Pre-Clinical experiments providing evidence that these experimental drugs work in animal models.  Could variable levels of Oxidative Stress in humans cause some of this failure?  If true, then there may be a simple way to improve the odds of an experimental drug working for Right To Try patients.  This approach should also interest Big Pharma.  An Oxidative Stress Test provides feedback on lifestyle choices for lowering Oxidative Stress.  This approach should be used prior to using experimental drugs for better results.

Elevated Blood Oxidative Stress May Impact Clinical Trials

The primary source of Oxidative Stress in adult Americans is from blood cells, which we call Blood Oxidative Stress or BLOS.  Although about 2/3 of adult Americans are thought to suffer from elevated levels of BLOS, medical researchers do NOT control it during Clinical Trials.  Control in this context means minimizing BLOS during the clinical trial.  But Big Pharma has been doing this for decades and this is the right approach for evaluating experimental drugs, right?

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New EBook Describes Health Hack for Life

New EBook Describes Health Hack for Life

Does Oxidative Stress confuse and worry you?  Which foods should I avoid?  What are antioxidants?  Will exercise help?  Do I have Oxidative Stress?   What is Oxidative StressHow does Oxidative Stress impact my health?  Is there a health hack for life that reduces Oxidative Stress?

Health Hack for Life

The answers to these questions and more are in my new eBook, “Let’s Hack Oxidative Stress.”  In my eBook, I provide a simple strategy for using three lifestyle choices to reduce your Oxidative Stress and improve your health.  You need to measure your Oxidative Stress with a Urine Test Kit to monitor the progress of your Hack.  The rest of the items needed for your Hack should be available at local stores, but there is a simpler way to gather up all of the products for  your Hack: Buy an Oxidative Stress Hack Kit from my Store!

Find All of Your BLOS Hack Kit Products Here

In addition to my eBook, I identified several high quality products for your Hack.  I have already done the shopping for you!  There are Oxidative Stress Hack Kits for either gender in both Deluxe and Basic formats.  The Lite Oxidative Stress Hack Kit is for the health-conscious person that already has most of the items needed for the Hack.  Get your life back on track by getting a handle on Oxidative Stress.

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Oxidative Stress Prevention Tips Improve Health

Can Lifestyle Choices Reduce Oxidative Stress?

Oxidative Stress is the major healthcare problem plaguing the United States, Europe, and other countries that adopted the Western Diet.  The major source of Oxidative Stress is from the blood, which presents major problems for management or prevention to improve health.  First, Blood Oxidative Stress or BLOS cannot be measured due to the lack of a proper method.  Second, BLOS is continuous (24/7), while General Oxidative Stress is temporary.  High, variable levels of Oxidative Stress depletes your body’s own antioxidants, whether from diet or the body.  Poor fitness in adult Americans also contributes to poor BLOS management due to minimal endogenous antioxidant production.  Endogenous means that your own body makes it.  Oxidative Stress prevention could be the key to improving health.

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What Are The Signs Of Oxidative Stress From Blood?

Is BLOS an Asymptomatic Disease?

The signs of oxidative stress from blood take years to fully develop, but early diagnosis may prevent many health problems.  The traditional approach to disease diagnosis is through the observation of one or more symptoms.  Rapid, accurate diagnosis is the key to treating symptomatic diseases.  Diseases that take years or decades to manifest as symptoms are Asymptomatic and rely on the underlying pathology for diagnosis.  Two examples of Asymptomatic Diseases are Alzheimer’s and Cardiovascular Diseases.  A recent news article describes how the Research Community redefined Alzheimer’s Disease as an Asymptomatic Disease.  In turn, this new definition will lead the development of new drugs for treating the underlying pathology before symptoms develop.  Blood Oxidative Stress or BLOS is another Asymptomatic Disease that demands more attention from the medical research community and public health officials.

Blood Oxidative Stress (BLOS)

Oxidative Stress receives lots of attention from medical researchers with new theories suggesting it causes multiple health problems including an increased risk of cancer.  There at least two sources of Oxidative Stress and Blood Oxidative Stress or BLOS may be the dominant source.  BLOS may be the true underlying cause of several diseases.  In fact, the underlying cause of Cardiovascular Disease may be BLOS, since it provides a mechanistic model for atherosclerosis that does not depend on a genetic mutation.

Learning about Signs of Oxidative Stress from Blood may prevent long-term development of serious health problems.
BLOS is another Asymptomatic Disease like Alzheimer’s and Cardiovascular Diseases. Learn about the signs of oxidative stress from blood in order to prevent long term health problems from developing.

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Blood Oxidative Stress Tests To Guide Lifestyle Choices

Review of Current and Future Tests for Measuring Oxidative Stress

Here is a list of the Top Oxidative Stress Tests available for evaluating your lifestyle choices.  These tests measure the level of different biomolecules that provide evidence of Oxidative Stress.  Oxidative Stress is thought to the the primary cause of multiple health problems.  Blood Oxidative Stress or BLOS is thought to be the main source of Oxidative Stress in humans.  If we have any hope in managing BLOS, then we need a way to measure its level.

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What is Oxidative Stress? It’s from the blood!

Blood Oxidative Stress is an Expensive Health Care Problem

What is Oxidative Stress?  Let’s review the two sources of Oxidative Stress and determine which source is more important.  General Oxidative Stress is thought to be the only source of Oxidative Stress.  However, Blood can also generate Oxidative Stress, which is also known as BLOS.  This post provides information about why BLOS is more important compared to General Oxidative Stress.  EBooks (and Books) and BLOS Health Hack Kits may help you fight BLOS for better health.

Second source of Oxidative Stress may be important to your health
Blood Oxidative Stress may be the primary source of Oxidative Stress causing multiple health problems.

General Oxidative Stress

The mechanistic model of General Oxidative Stress starts with an elevated rate of metabolism that results in mitochondrial dysfunction.  In turn, this leads to an increased production of reactive oxygen species (ROS).   Medical researchers observe General Oxidative Stress in tissue cultures, but it is difficult to observe in the human body.  How many biopsies are needed to identify the tissues sources of General Oxidative Stress?  Instead, medical researchers rely on diagnostic methods that evaluate ROS or oxidation end products in blood, urine, or breath.

General Oxidative Stress and ROS

ROS includes O2 (superoxide radical), OH (hydroxyl radical) and H2O2 (hydrogen peroxide).  Most folks are familiar with the many uses of hydrogen peroxide for cleaning, disinfecting, and more.  For your health, excessive production of ROS including hydrogen peroxide can be dangerous.  The ROS molecules diffuse into the bloodstream and react with biomolecules throughout the body.  The end products of these ROS reactions can be measured in blood, urine, and breath.  The general consensus on the primary cause of General Oxidative Stress is the high caloric content of the Western Diet.

Excessive alcohol consumption is a special case of General Oxidative Stress.  It causes short periods of ROS generation in the liver and other organs.  Short periods of ROS generation is a primary characteristic of General Oxidative Stress.  It is due to the reliance on excessive substrate availability necessary for the elevated rate of metabolism.  A second source of Oxidative Stress is from blood cells, which received little attention from medical researchers or the general public.

Blood Oxidative Stress

White blood cells and platelets can generate high rates of ROS, which is alarming when the patient does not have an infection.  In 2008, Walter Paulus’ research group reported on ROS+ blood cells in both healthy (non-hospitalized) and congestive heart failure (CHF) patients.  Here is the link for the Abstract of the research article describing Blood Oxidative Stress or BLOS: https://www.ncbi.nlm.nih.gov/pubmed/18957960  This article provides interesting BLOS data and I will focus on the most important findings, which escaped the attention of the researchers.  The research community missed it, but this is understandable when you consider that there are over 200,000 research articles about Oxidative Stress.  The Paulus’ paper is the proverbial “needle in the haystack” for Oxidative Stress.

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Top 3 Antioxidant Supplements to Lower Oxidative Stress

Which Antioxidant Supplements Work The Best For Blood Oxidative Stress?

A review of the current medical research suggests that three Antioxidant Supplements may reduce Oxidative Stress for improved health.

Oxidative Stress

The two reported sources of Oxidative Stress are General and Blood Oxidative Stress or BLOS.  General Oxidative Stress is the more familiar due to its earlier discovery.  However, BLOS is probably the primary cause of Oxidative Stress.  General Oxidative Stress results from short periods of elevated metabolism rates within cells that generates reactive oxygen species (ROS).  In contrast, BLOS is a large fraction of your blood cells induced to generate high levels of ROS.  Long term, elevated BLOS is the probable cause of multiple health problems.  More than 2/3 of adult Americans suffer from BLOS.  Both sources of Oxidative Stress result in high levels of ROS that diffuse throughout the body causing damage and health problems.  Although your body does produce low levels of antioxidant, excessive ROS may require an antioxidant supplement to manage Oxidative Stress.

Antioxidant supplements could manage BLOS
Where does BLOS come from? The Western Diet!

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Avoid These 5 Foods That Cause Blood Oxidative Stress

Which foods cause blood oxidative stress or BLOS?

Here is a list of the Top 5 Foods to avoid, if you want to reduce Oxidative Stress and improve your health.  Avoiding ultra-processed foods may reduce your risk of cancer, but are they all bad for you?  Many ultra-processed foods have one thing in common: high levels of inorganic sulfur.  This type of sulfur leads to the growth of sulfate reducing bacteria (SRB) in your gut, which may cause your blood cells to generate high levels of reactive oxygen species (ROS), the primary source of Oxidative Stress.  In the long term, high levels of ROS can damage DNA, which can cause cancer.

Western Diet has many foods rich in sulfur that cause BLOS
Where does BLOS come from? The Western Diet! Low BLOS Foods may be the key to managing BLOS.

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BLOS World Has Best Information to Reduce Oxidative Stress!

BLOS World provides a review of the best information and products to reduce Oxidative Stress.  Why should you worry about Oxidative Stress?  Start with learning more about Oxidative Stress generated by your blood.

What is Blood Oxidative Stress?

Blood Oxidative Stress (BLOS) is probably the primary cause of Oxidative Stress.  In BLOS, activated blood cells generate high levels of reactive oxygen species (ROS).  However, reducing the amount of inorganic sulfur in the diet and adding effective antioxidant supplements may manage BLOS.  About 2/3 adult Americans are thought to suffer from elevated BLOS.  BLOS extends beyond the USA with Europe and countries that adopted the Western Diet.  The effective management of BLOS may be the key to treating several health problems including Obesity, Type 2 Diabetes, Hypertension, and the risk of Cancer.  In the USA, BLOS is thought to be responsible for annual healthcare costs of more than $800B.

Reduce Oxidative Stress by consuming foods and supplements rich in antioxidants.
Foods and Supplements rich in antioxidants may reduce oxidative stress

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