What is Oxidative Stress? Let’s review the two sources of Oxidative Stress and determine which source is more important. General Oxidative Stress is thought to be the only source of Oxidative Stress. However, Blood can also generate Oxidative Stress, which is also known as BLOS. This post provides information about why BLOS is more important compared to General Oxidative Stress. EBooks (and Books) and BLOS Health Hack Kits may help you fight BLOS for better health.
General Oxidative Stress
The mechanistic model of General Oxidative Stress starts with an elevated rate of metabolism that results in mitochondrial dysfunction. In turn, this leads to an increased production of reactive oxygen species (ROS). Medical researchers observe General Oxidative Stress in tissue cultures, but it is difficult to observe in the human body. How many biopsies are needed to identify the tissues sources of General Oxidative Stress? Instead, medical researchers rely on diagnostic methods that evaluate ROS or oxidation end products in blood, urine, or breath.
General Oxidative Stress and ROS
ROS includes O2− (superoxide radical), OH (hydroxyl radical) and H2O2 (hydrogen peroxide). Most folks are familiar with the many uses of hydrogen peroxide for cleaning, disinfecting, and more. For your health, excessive production of ROS including hydrogen peroxide can be dangerous. The ROS molecules diffuse into the bloodstream and react with biomolecules throughout the body. The end products of these ROS reactions can be measured in blood, urine, and breath. The general consensus on the primary cause of General Oxidative Stress is the high caloric content of the Western Diet.
Excessive alcohol consumption is a special case of General Oxidative Stress. It causes short periods of ROS generation in the liver and other organs. Short periods of ROS generation is a primary characteristic of General Oxidative Stress. It is due to the reliance on excessive substrate availability necessary for the elevated rate of metabolism. A second source of Oxidative Stress is from blood cells, which received little attention from medical researchers or the general public.
Blood Oxidative Stress
White blood cells and platelets can generate high rates of ROS, which is alarming when the patient does not have an infection. In 2008, Walter Paulus’ research group reported on ROS+ blood cells in both healthy (non-hospitalized) and congestive heart failure (CHF) patients. Here is the link for the Abstract of the research article describing Blood Oxidative Stress or BLOS: https://www.ncbi.nlm.nih.gov/pubmed/18957960 This article provides interesting BLOS data and I will focus on the most important findings, which escaped the attention of the researchers. The research community missed it, but this is understandable when you consider that there are over 200,000 research articles about Oxidative Stress. The Paulus’ paper is the proverbial “needle in the haystack” for Oxidative Stress.