Can Vitamin C reduce Oxidative Stress? Vitamin C has antioxidant properties, which means that it reacts with reactive oxygen species (ROS) to neutralize it. There are reports of Vitamin C being an ineffective antioxidant supplement. However, a mismatch of the supplement format compared to the source of Oxidative Stress may be the cause. Supplements come in three main formats, which provide the release of the compounds immediate, time, or sustained release.
The immediaterelease is usually a tablet format or chewable. This format provides a near instantaneous increase in the concentration of the compound in the blood. This assumes implied losses due to stomach digestion and absorption prior to entry into the blood stream.
With time-release, the format prevents rapid capsule digestion in the stomach with release in the small intestine. Time-release is not immediate, but it does avoid losses due to stomach digestion. Both immediate and time-release formats provide a short-term spike in compound concentration in the bloodstream.
With sustained-release, the capsule releases the compounds over several hours, which will provide a steady, low concentration of the compound(s) in the blood stream. Which supplement format is the best for antioxidant effectiveness?
What is Oxidative Stress? Let’s review the two sources of Oxidative Stress and determine which source is more important. General Oxidative Stress is thought to be the only source of Oxidative Stress. However, Blood can also generate Oxidative Stress, which is also known as BLOS. This post provides information about why BLOS is more important compared to General Oxidative Stress. EBooks (and Books) and BLOS Health Hack Kits may help you fight BLOS for better health.
General Oxidative Stress
The mechanistic model of General Oxidative Stress starts with an elevated rate of metabolism that results in mitochondrial dysfunction. In turn, this leads to an increased production of reactive oxygen species (ROS). Medical researchers observe General Oxidative Stress in tissue cultures, but it is difficult to observe in the human body. How many biopsies are needed to identify the tissues sources of General Oxidative Stress? Instead, medical researchers rely on diagnostic methods that evaluate ROS or oxidation end products in blood, urine, or breath.
Excessive alcohol consumption is a special case of General Oxidative Stress. It causes short periods of ROS generation in the liver and other organs. Short periods of ROS generation is a primary characteristic of General Oxidative Stress. It is due to the reliance on excessive substrate availability necessary for the elevated rate of metabolism. A second source of Oxidative Stress is from blood cells, which received little attention from medical researchers or the general public.
Blood Oxidative Stress
White blood cells and platelets can generate high rates of ROS, which is alarming when the patient does not have an infection. In 2008, Walter Paulus’ research group reported on ROS+ blood cells in both healthy (non-hospitalized) and congestive heart failure (CHF) patients. Here is the link for the Abstract of the research article describing Blood Oxidative Stress or BLOS: https://www.ncbi.nlm.nih.gov/pubmed/18957960 This article provides interesting BLOS data and I will focus on the most important findings, which escaped the attention of the researchers. The research community missed it, but this is understandable when you consider that there are over 200,000 research articles about Oxidative Stress. The Paulus’ paper is the proverbial “needle in the haystack” for Oxidative Stress.
BLOS World provides a review of the best information and products to reduce Oxidative Stress. Why should you worry about Oxidative Stress? Start with learning more about Oxidative Stress generated by your blood.
What is Blood Oxidative Stress?
Blood Oxidative Stress (BLOS) is probably the primary cause of Oxidative Stress. In BLOS, activated blood cells generate high levels of reactive oxygen species (ROS). However, reducing the amount of inorganic sulfur in the diet and adding effective antioxidant supplements may manage BLOS. About 2/3 adult Americans are thought to suffer from elevated BLOS. BLOS extends beyond the USA with Europe and countries that adopted the Western Diet. The effective management of BLOS may be the key to treating several health problems including Obesity, Type 2 Diabetes, Hypertension, and the risk of Cancer. In the USA, BLOS is thought to be responsible for annual healthcare costs of more than $800B.