Can Vitamin C reduce Oxidative Stress? Vitamin C has antioxidant properties, which means that it reacts with reactive oxygen species (ROS) to neutralize it. There are reports of Vitamin C being an ineffective antioxidant supplement. However, a mismatch of the supplement format compared to the source of Oxidative Stress may be the cause. Supplements come in three main formats, which provide the release of the compounds immediate, time, or sustained release.
The immediaterelease is usually a tablet format or chewable. This format provides a near instantaneous increase in the concentration of the compound in the blood. This assumes implied losses due to stomach digestion and absorption prior to entry into the blood stream.
With time-release, the format prevents rapid capsule digestion in the stomach with release in the small intestine. Time-release is not immediate, but it does avoid losses due to stomach digestion. Both immediate and time-release formats provide a short-term spike in compound concentration in the bloodstream.
With sustained-release, the capsule releases the compounds over several hours, which will provide a steady, low concentration of the compound(s) in the blood stream. Which supplement format is the best for antioxidant effectiveness?
If Black Swan in the title got your attention, then you are already familiar with Nassim Taleb’s work on Black Swans. Beyond the financial sector, there is interest in predicting Black Swans in other sectors including Health Care. What if the Black Swan for Health Care isn’t a digital product or novel class of promising drugs? What if it’s a new, broad impacting asymptomatic disease that escaped the attention of medical researchers and the general public? This potential Black Swan is Blood Oxidative Stress or BLOS. An estimated 2/3 of adult Americans suffer from BLOS costing $1T/year in Health Care costs. BLOS extends beyond the USA impacting Europe and many countries that adopted the Western Diet.
What is Blood Oxidative Stress (BLOS)?
Blood Oxidative Stress or BLOS is a high percentage of blood cells generating reactive oxygen species (ROS). Once induced to generate ROS, these blood cells generate it until replacement (about 1 week). The high prevalence of BLOS in Western Countries suggests that the Western Diet may be the culprit. One theory suggests that excessive dietary inorganic sulfur may lead to the proliferation of sulfate reducing bacteria (SRB) in the gut. Many food preservatives and additives contain inorganic sulfur, which is common in the Western Diet. In turn, these SRB have the potential to generate high amounts of sulfide in the gut. Short bursts of sulfide production in the gut are thought to induce the ROS response in captive blood cells.
If Blood Oxidative Stress or BLOS impacts your pet’s health, then an antioxidant supplement may help reduce BLOS and improve your pet’s health. BLOS has been suggested as a cause of Obesity and Diabetes, since it can inhibit glucose transport and fat metabolism. There is a growing problem of obesity and diabetes in our pets. Are we feeding our pets too much or is it something in the food causing BLOS? Here is s an in-depth guide to the problem of obesity in dogs. Beyond pet food, we may be able help our pets by providing an effective antioxidant supplement. Could antioxidant supplements consisting of effective antioxidants and designed for time-release help your pet? We reviewed the scientific research and provided a short list of the Best Antioxidant Supplements for your Pet.
Oxidative Stress is the major healthcare problem plaguing the United States, Europe, and other countries that adopted the Western Diet. The major source of Oxidative Stress is from the blood, which presents major problems for management or prevention to improve health. First, Blood Oxidative Stress or BLOS cannot be measured due to the lack of a proper method. Second, BLOS is continuous (24/7), while General Oxidative Stress is temporary. High, variable levels of Oxidative Stress depletes your body’s own antioxidants, whether from diet or the body. Poor fitness in adult Americans also contributes to poor BLOS management due to minimal endogenous antioxidant production. Endogenous means that your own body makes it. Oxidative Stress prevention could be the key to improving health.
The signs of oxidative stress from blood take years to fully develop, but early diagnosis may prevent many health problems. The traditional approach to disease diagnosis is through the observation of one or more symptoms. Rapid, accurate diagnosis is the key to treating symptomatic diseases. Diseases that take years or decades to manifest as symptoms are Asymptomatic and rely on the underlying pathology for diagnosis. Two examples of Asymptomatic Diseases are Alzheimer’s and Cardiovascular Diseases. A recent news article describes how the Research Community redefined Alzheimer’s Disease as an Asymptomatic Disease. In turn, this new definition will lead the development of new drugs for treating the underlying pathology before symptoms develop. Blood Oxidative Stress or BLOS is another Asymptomatic Disease that demands more attention from the medical research community and public health officials.
Blood Oxidative Stress (BLOS)
Oxidative Stress receives lots of attention from medical researchers with new theories suggesting it causes multiple health problems including an increased risk of cancer. There at least two sources of Oxidative Stress and Blood Oxidative Stress or BLOS may be the dominant source. BLOS may be the true underlying cause of several diseases. In fact, the underlying cause of Cardiovascular Disease may be BLOS, since it provides a mechanistic model for atherosclerosis that does not depend on a genetic mutation.
What is Oxidative Stress? Let’s review the two sources of Oxidative Stress and determine which source is more important. General Oxidative Stress is thought to be the only source of Oxidative Stress. However, Blood can also generate Oxidative Stress, which is also known as BLOS. This post provides information about why BLOS is more important compared to General Oxidative Stress. EBooks (and Books) and BLOS Health Hack Kits may help you fight BLOS for better health.
General Oxidative Stress
The mechanistic model of General Oxidative Stress starts with an elevated rate of metabolism that results in mitochondrial dysfunction. In turn, this leads to an increased production of reactive oxygen species (ROS). Medical researchers observe General Oxidative Stress in tissue cultures, but it is difficult to observe in the human body. How many biopsies are needed to identify the tissues sources of General Oxidative Stress? Instead, medical researchers rely on diagnostic methods that evaluate ROS or oxidation end products in blood, urine, or breath.
Excessive alcohol consumption is a special case of General Oxidative Stress. It causes short periods of ROS generation in the liver and other organs. Short periods of ROS generation is a primary characteristic of General Oxidative Stress. It is due to the reliance on excessive substrate availability necessary for the elevated rate of metabolism. A second source of Oxidative Stress is from blood cells, which received little attention from medical researchers or the general public.
Blood Oxidative Stress
White blood cells and platelets can generate high rates of ROS, which is alarming when the patient does not have an infection. In 2008, Walter Paulus’ research group reported on ROS+ blood cells in both healthy (non-hospitalized) and congestive heart failure (CHF) patients. Here is the link for the Abstract of the research article describing Blood Oxidative Stress or BLOS: https://www.ncbi.nlm.nih.gov/pubmed/18957960 This article provides interesting BLOS data and I will focus on the most important findings, which escaped the attention of the researchers. The research community missed it, but this is understandable when you consider that there are over 200,000 research articles about Oxidative Stress. The Paulus’ paper is the proverbial “needle in the haystack” for Oxidative Stress.
Hypertension is one of many health problems associated with Oxidative Stress. In the fight against Oxidative Stress, improved fitness often takes the backseat to dietary changes. Some folks think that a regimen of low-dose aspirin will reduce their risk of heart attack or stroke. Recent research suggests that this idea is wrong. The idea of exercise is dreadful for most people, especially as they get older and life gets more complicated. This post provides information on a simple fitness tip that reduces Hypertension. Always consult with your physician before making any changes in your exercise routine and diet (read our Disclaimer below).
A review of the current medical research suggests that three Antioxidant Supplements may reduce Oxidative Stress for improved health.
The two reported sources of Oxidative Stress are General and Blood Oxidative Stress or BLOS. General Oxidative Stress is the more familiar due to its earlier discovery. However, BLOS is probably the primary cause of Oxidative Stress. General Oxidative Stress results from short periods of elevated metabolism rates within cells that generates reactive oxygen species (ROS). In contrast, BLOS is a large fraction of your blood cells induced to generate high levels of ROS. Long term, elevated BLOS is the probable cause of multiple health problems. More than 2/3 of adult Americans suffer from BLOS. Both sources of Oxidative Stress result in high levels of ROS that diffuse throughout the body causing damage and health problems. Although your body does produce low levels of antioxidant, excessive ROS may require an antioxidant supplement to manage Oxidative Stress.