Oxidative Stress Blood Test Good for Patients and Pharma

How does Oxidative Stress Impact Clinical Trials?

The Right To Try Bill is a new Law, which offers hope for terminally ill patients interested in trying experimental drugs that passed Phase 1 safety standards from the FDA.  While encouraging, the grim reality of experimental drugs is that a large majority fail in Phase 2/3 of Clinical Trials.  This is despite Pre-Clinical experiments providing evidence that these experimental drugs work in animal models.  Could variable levels of Oxidative Stress in humans cause some of this failure?  If true, then there may be a simple way to improve the odds of an experimental drug working for Right To Try patients.  This approach should also interest Big Pharma.  An Oxidative Stress Test provides feedback on lifestyle choices for lowering Oxidative Stress.  This approach should be used prior to using experimental drugs for better results.

Elevated Blood Oxidative Stress May Impact Clinical Trials

The primary source of Oxidative Stress in adult Americans is from blood cells, which we call Blood Oxidative Stress or BLOS.  Although about 2/3 of adult Americans are thought to suffer from elevated levels of BLOS, medical researchers do NOT control it during Clinical Trials.  Control in this context means minimizing BLOS during the clinical trial.  But Big Pharma has been doing this for decades and this is the right approach for evaluating experimental drugs, right?

Simple Analogy of the Evaluation of a Smart Fire Extinguisher

A simple analogy can help people, even smart people that run pharmaceutical companies, see a problem clearly.

New Products Require Systematic Testing Before Going to Market

Let’s start with a small company that designed a smart fire extinguisher and wants to evaluate it before going to market.

Let’s start with a pharmaceutical company that designed a new drug to treat a hypothetical disease and wants to evaluate it and get FDA approval. 

First Product Test is the Easiest Test

This smart fire extinguisher can be controlled via radio signal by an operator off-site.  The company starts with a simple pre-market experiment where the smart fire extinguisher puts out a fire in a room. The company is blissfully unaware that the real-world has a larger number of fires with radio interference.  So, they didn’t bother testing their product with radio interference.

The pharmaceutical company uses a pre-clinical experiment to demonstrate that the experimental drug treats an animal model with the disease. The animal model does not have BLOS.

Final Product Tests are the Most Difficult Tests – Real World!

With great results, the company decides to test their product in a real-world building.  If it doesn’t work in a real-world building, then nobody will buy it.

With great pre-clinical results, the pharmaceutical company decides to test their product in humans (Phase2/3).  If it doesn’t work in humans, then the FDA will not approve it for sale.

This trial involves real buildings with fires, but there is no effort to characterize the building.  Now, it is obvious that more than half of the burning buildings also have radio interference.  So, the fire extinguisher designed for ideal conditions is challenged by a fire in a building where radio interference is prevalent.  Will it impact the effectiveness of the smart fire extinguisher?  The smart fire extinguisher fails the test, because the off-site operator can’t control it.

The experimental drug fails in Phase2/3, because they didn’t control BLOS prior to the clinical trial.

Is Big Pharma Stuck On Stupid?

Don’t worry dear reader.  Pharmaceutical ompanies will continue to spend billions of dollars to develop experimental drugs in the same broken way.  Why don’t they consider a simple approach to control BLOS before Phase2/3 trials?

Oxidative Stress Blood Test could reduce the failure rate of clinical trials
Oxidative Stress Blood Test may be the key to improving the success rate of clinical trials.

Should BLOS be of concern for Right To Try patients?  Yes, BLOS is a continuous source of reactive oxygen species (ROS), which diffuses into tissue throughout the body causing havoc.  High concentration of ROS (i.e., Oxidative Stress) impacts drug effectiveness in two ways: 1) oxidizes the drug into either non-functioning compounds or more dangerous compounds  2) inhibits drug transport.

Use Oxidative Stress Blood Test Before Trying Experimental Drug

A new Oxidative Stress Blood Test (BLOS#) is under development, but there is an alternative available right now.  The simplest strategy for lowering Oxidative Stress requires the use of a Urine Test Kit, which measures the degree of Oxidative Stress in your blood via the urine.  I provided several posts (free) on my blog on how to change lifestyle choices to reduce Oxidative Stress.  Instead of reading all of my blog posts looking for answers, I compiled the best posts in my new eBook.  This eBook provides guidance on how to use three lifestyle choices to reduce your Oxidative Stress.

Step 1 Evaluate Your Oxidative Stress

Determine whether you suffer from Oxidative Stress by using the Urine Test Kit.

Step 2 Review and Change Your Lifestyle Choices to Lower Oxidative Stress

Change your lifestyle and use the Urine Test Kit to determine whether your lifestyle changes lowered Oxidative Stress.

Step 3 Use Experimental Drug

Start the experimental drug and provide feedback to your physician and the Pharmaceutical company about your strategy to lower Oxidative Stress before using their experimental drug.

Big Pharma Should Embrace Oxidative Stress Blood Test

This strategy be of interest to Big Pharma, because it offers the potential to reduce the failure rate of experimental drugs.  Pharmaceutical companies should use this as an opportunity to learn about how BLOS may impact their product.  The simplest approach would be for a donation of my eBook and the Urine Test Kit to any Right To Try patient interested in trying to lower BLOS before using the experimental drug.  With proper lifestyle choices, a person should be able to reduce BLOS in about 1-2 weeks.  The Urine Test Kit is the key to ensuring minimal BLOS before starting the experimental drug.  This approach could also generate results for Fast Track applications for experimental drugs that meet an unmet need.

As always, read my disclaimer and always consult with your physician before making any changes in your diet or fitness regime.

Click on the image below to download our Free Report on the Best Vitamin C Supplement for fighting Oxidative Stress.

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Learn How to Enhance Probiotics for Women and Men

Learn how to Enhance Probiotics for Women and Men by Reducing Oxidative Stress

Probiotics are found in supplements and food items with the promise of a health benefit.  However, the FDA has yet to approve any probiotic for the treatment of any human disease.  While animal studies provide evidence that probiotics may be an effective treatment for health problems, human studies always come up short.  There may be a simple explanation for this observation: Oxidative Stress.  Learn how to enhance probiotics for women and men by reducing and managing Oxidative Stress.

Oxidative Stress Selects Against Catalase Negative Bacteria

More than 2/3 of adult Americans suffering from elevated levels of Oxidative Stress, hence it may impact clinical trials.  Blood Oxidative Stress or BLOS is the primary source of Oxidative Stress.  BLOS is the continuous production of reactive oxygen species (ROS) by blood cells.  Blood Oxidative Stress is a problem for microorganisms that are catalase negative.  Some bacteria generate catalase to counter or neutralize ROS, which are the predominant molecules associated with Oxidative Stress.  So, elevated levels of BLOS make catalase negative bacteria vulnerable.

Bifidobacteria and Lactobacillus strains are the most popular probiotic strains used in a variety of supplements and food item.  However, both genera are catalase negative.  Consequently, if you suffer from elevated BLOS, then these probiotics may not provide any health benefit since they die in the gut environment.  This also suggests that management of BLOS will improve the performance of these probiotic strains.

Is there any hope for Probiotics?

Reduced levels of Oxidative Stress should improve the health benefit of your favorite probiotic.  A simple strategy evaluates lifestyle choices aimed at reducing Oxidative Stress.  An inexpensive Urine Oxidative Stress test kit is available to evaluate dietary choices.  I’ve combined my ebook and the Urine Oxidative Stress test kit with other products in a range of BLOS Hack Kits.

Infographic describing the components of the BLOS Hack Kits

This approach offers the potential for improving conditions for the probiotic bacteria to flourish in the gut.  I offer such a strategy in my new ebook.   Folks disappointed in the performance of their probiotics may want to read my ebook.

Why Probiotic Vendors Should Learn How to Enhance Probiotics for Women and Men

Finally, leading probiotic vendors should take note.  Which vendor will be the first one to setup a clinical study to evaluate whether BLOS management improves probiotic performance?  The strategy that I provide in my new ebook would add a negligible cost to a clinical trial.  Recently I suggested the same strategy for pharmaceutical companies and Right To Try patientsDiabetes Prevention Programs could also use this approach and focus on reducing Oxidative Stress instead of Weight.

It’s the Blood Oxidative Stress Dummies!

Click on the image below to download our Free Report on the Best Vitamin C Supplement for fighting Oxidative Stress.

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New EBook Describes Health Hack for Life

New EBook Describes Health Hack for Life

Does Oxidative Stress confuse and worry you?  Which foods should I avoid?  What are antioxidants?  Will exercise help?  Do I have Oxidative Stress?   What is Oxidative StressHow does Oxidative Stress impact my health?  Is there a health hack for life that reduces Oxidative Stress?

Health Hack for Life

The answers to these questions and more are in my new eBook, “Let’s Hack Oxidative Stress.”  In my eBook, I provide a simple strategy for using three lifestyle choices to reduce your Oxidative Stress and improve your health.  You need to measure your Oxidative Stress with a Urine Test Kit to monitor the progress of your Hack.  The rest of the items needed for your Hack should be available at local stores, but there is a simpler way to gather up all of the products for  your Hack: Buy an Oxidative Stress Hack Kit from my Store!

Find All of Your BLOS Hack Kit Products Here

In addition to my eBook, I identified several high quality products for your Hack.  I have already done the shopping for you!  There are Oxidative Stress Hack Kits for either gender in both Deluxe and Basic formats.  The Lite Oxidative Stress Hack Kit is for the health-conscious person that already has most of the items needed for the Hack.  Get your life back on track by getting a handle on Oxidative Stress.

Infographic describing the components of the BLOS Hack Kits
BLOS Hack Kits for You!

Deluxe Oxidative Stress Hack Kits

These Deluxe Oxidative Stress Hack Kits include my eBook and everything that you need for your Hack.  All you need is your shoe size!  Each Deluxe Oxidative Stress Hack Kit includes all of the fitness equipment (shoes, heart rate monitor, blood pressure monitor), three different effective Antioxidant supplements, and the Urine Test Kit.

Men’s Deluxe Hack Kit

Women’s Deluxe Hack Kit

Basic Oxidative Stress Hack Kits

These Basic Oxidative Stress Hack Kits include my eBook and minimal collections of products that should be effective for your Hack.  Each Basic Oxidative Stress Hack Kit includes the minimal fitness equipment (shoes, heart rate monitor), two different effective Antioxidant supplements, and the Urine Test Kit.

Men’s Basic Hack Kit

Women’s Basic Hack Kit

Lite Hack Oxidative Stress Kit

The Lite Oxidative Stress Hack Kit provides my eBook and the Urine Test Kit to measure your Oxidative Stress.  Browse my BLOS World Store for any individual products needed for your Hack.

For a modest investment, a Health Hack for Life is available.  Read my eBook, use the strategy, and share your Hack results.  It is that simple!

All proceeds support BLOS Research.

Click on the image below to download our Free Report on the Best Vitamin C Supplement for fighting Oxidative Stress.

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Effective Supplement of Vitamin C Reduces Oxidative Stress

Can you eat enough fruit to be an effective antioxidant?

Can Vitamin C reduce Oxidative Stress?  Vitamin C has antioxidant properties, which means that it reacts with reactive oxygen species (ROS) to neutralize it.  There are reports of Vitamin C being an ineffective antioxidant supplement.  However, a mismatch of the supplement format compared to the source of Oxidative Stress may be the cause.  Supplements come in three main formats, which provide the release of the compounds immediate, time, or sustained release.

Immediate Release

The immediate release is usually a tablet format or chewable.  This format provides a near instantaneous increase in the concentration of the compound in the blood.  This assumes implied losses due to stomach digestion and absorption prior to entry into the blood stream.

Time-Release

With time-release, the format prevents rapid capsule digestion in the stomach with release in the small intestine.  Time-release is not immediate, but it does avoid losses due to stomach digestion.  Both immediate and time-release formats provide a short-term spike in compound concentration in the bloodstream.

Sustained-Release

With sustained-release, the capsule releases the compounds over several hours, which will provide a steady, low concentration of the compound(s) in the blood stream. Which supplement format is the best for antioxidant effectiveness?

Intravenous Vitamin C Reduces Oxidative Stress

A recent news article reported on the use of an intravenous (IV) cocktail including Vitamin C to treat patients with sepsis demands our attention.  Blood Oxidative Stress or BLOS is blood cells generating high levels of reactive oxygen species (ROS), which is the primary source of Oxidative Stress.  In patients with sepsis, both BLOS and General Oxidative Stress (GOS) contribute to overall Oxidative Stress.  According to the article, Vitamin C provided by IV is effective at neutralizing the ROS compounds and reducing Oxidative Stress.  This could be good news for folks (without sepsis) interested in managing Oxidative Stress, which are more than 2/3 of adult Americans.

The reduction and management of BLOS is possible by either preventing the ROS induction of blood cells or neutralizing the ROS in the blood stream through the use of an antioxidant supplement.  With BLOS, the activated blood cells keep producing ROS 24/7 (i.e., continuous).  This suggests that a sustained-release supplement with Vitamin C (and other antioxidants) is the only effective format for an antioxidant supplement to reduce the impact of BLOS.  Be careful and read those product labels.

Keep this in mind:  Vitamin C used as an antioxidant supplement is different than meeting the Recommended Daily Allowance (RDA).  The RDA refers to what your body requires without Oxidative Stress.  What is the right dose for you?  Talk with your physician and consider ways to measure your current level of Oxidative Stress, such as a Urine Strip Test Kit, which will guide your dosage rate.

Purchase Supplements of Vitamin C that Reduces Oxidative Stress Here!

If you cannot find a high quality Vitamin C supplement at your local health food store, then consider these two high quality supplements available through Amazon.

NOW Vitamin C-1000 Sustained Release

Bronson Vitamin C Sustained Release

Be sure to check with your physician on the use of any new dietary supplement and pay attention to the maximum daily dosage limit and any potential complications due to your current health state.

BLOS World Store Offers Great Products Including BLOS Hack Kits

If you’re serious about reducing your Oxidative Stress, then you should consider our BLOS Hack Kits.  These kits include my new eBook, Urine Oxidative Stress test kit, and different products to fit your needs.  Start with my eBook and then select the products that you will need to Hack BLOS!

Infographic describing the components of the BLOS Hack Kits

 

Click on the image below to download our Free Report on the Best Vitamin C Supplement for fighting Oxidative Stress.

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BLOS is a Positive Black Swan for Health Care

BLOS could be a Positive Black Swan for Health Care.

If Black Swan in the title got your attention, then you are already familiar with Nassim Taleb’s work on Black Swans.  Beyond the financial sector, there is interest in predicting Black Swans in other sectors including Health Care.  What if the Black Swan for Health Care isn’t a digital product or novel class of promising drugs?  What if it’s a new, broad impacting asymptomatic disease that escaped the attention of medical researchers and the general public?  This potential Black Swan is Blood Oxidative Stress or BLOS.  An estimated 2/3 of adult Americans suffer from BLOS costing $1T/year in Health Care costs.  BLOS extends beyond the USA impacting Europe and many countries that adopted the Western Diet.

 

Blood Oxidative Stress may be the Black Swan for Health Care
BLOS could be the Positive Black Swan for Health Care.

What is Blood Oxidative Stress (BLOS)?

Blood Oxidative Stress or BLOS is a high percentage of blood cells generating reactive oxygen species (ROS).  Once induced to generate ROS, these blood cells generate it until replacement (about 1 week).  The high prevalence of BLOS in Western Countries suggests that the Western Diet may be the culprit.  One theory suggests that excessive dietary inorganic sulfur may lead to the proliferation of sulfate reducing bacteria (SRB) in the gut.  Many food preservatives and additives contain inorganic sulfur, which is common in the Western Diet.  In turn, these SRB have the potential to generate high amounts of sulfide in the gut.  Short bursts of sulfide production in the gut are thought to induce the ROS response in captive blood cells.

Can we measure BLOS?

Management of any process requires the ability to measure outcomes, which allows for the evaluation of methods to control the process.  BLOS is painless, which makes it difficult for physicians to observe in patients.  It’s one of the reasons that it escaped our attention.  However, flow cytometry measures BLOS, but it is not FDA approved and expensive.  An inexpensive, FDA approved method to measure BLOS will evaluate BLOS management strategies.  One approach for BLOS management involves lifestyle changes that focus on fitness and dietary changes.  Down the road, new drugs may target the ROS response in blood cells.  There are a few commercial test kits that measure the end products of Oxidative Stress, which may be useful for evaluating lifestyle changes right now.

Free Urine Oxidative Stress Kits for Diabetes Prevention Programs or Drug Trials

I proposed the use of the Urine Oxidative Stress test kit to improve Diabetes Prevention Programs and Clinical Trials.  In fact, I offered to purchase the Urine Oxidative Stress kit for a Diabetes Prevention Program.  This approach may improve the effectiveness of these programs by focusing on BLOS management instead of weight management.  I will extend this offer to any pharmaceutical company that wants to evaluate whether BLOS management improves the performance of a clinical trial.  What have you got to lose besides millions of dollars in another failed Phase2/3 clinical trial.  Send me an email, if there’s interest in partnering. 

Impact of BLOS as Black Swan for Health Care Industry

Eventually, BLOS will emerge as a major health issue and graduate to Black Swan status for the Health Care Industry.  Here is a list of the potential impacts of BLOS on Health Care and associated industries.

Health Care

BLOS management may reverse the damage caused by long-term, elevated BLOS or at the very least, prevent the progression of any health problems.  Healthcare facilities will offer BLOS management support.  The BLOS# test will become the “gold standard” of patient health, since it directly measures the causative agent of BLOS.  Urine oxidative stress and other oxidative stress tests measure the end products of BLOS, so they will not be used as a disease diagnostic.

Insurance

Health Care insurance costs should lower with widespread success of BLOS management to reduce the burden of expensive illnesses.  Don’t be surprised if you see new Life insurance policies that reward healthy policy holders that demonstrate BLOS management.

Wellness Programs

BLOS management may become the center piece of corporate Wellness programs, since BLOS impacts so many employees.  BLOS management will provide better guidance to employees on lifestyle changes needed to improve health.

Agriculture

Major change in the Food Industry to reduce or eliminate any component of the Western Diet that causes BLOS.  These changes in the Western Diet would continue the current trend of clean eating.  If inorganic sulfur is identified as the main cause of BLOS, then new food preservatives and additives will be needed.

Pharmaceuticals

Elevated BLOS probably impacts the efficacy of pharmaceuticals due to the oxidation of drugs and inhibited drug transport by ROS.  In addition, elevated BLOS may be the cause of the high rate of failed clinical trials due to the lack of control of BLOS.  Management of BLOS may improve the success rate of clinical trials.  Consequently, this would reduce the cost of pharmaceutical development and lower the retail price.  However, BLOS management may be effective at treating many illnesses.  This would eliminate the need for any current or new drugs in the pipeline.

BLOS may be cause of failed clinical trials
BLOS Management may be the key to improving the success rate of clinical trials.

BLOS is a Positive Black Swan for Health Care

The health care cost savings potential of BLOS management is enormous, which will result in both winners and losers in the Economy.

The Winners

The winners will be the folks currently suffering from elevated BLOS, who may look forward to much better health and a longer lifespan.  Worker productivity should benefit from this shift immediately.  Many workers in poor health miss time due to sick days and visits to their physician.  How many do not perform at their highest level due to poor health at the workplace?  Many retirees in poor health may regain their health and decide to return to the workforce.  This would also be a boon for the Economy in the form of an increase in the supply of Experience.

The Losers

The major losers will be companies, non-profits, academic institutions, and government agencies that fail to adapt to the new BLOS landscape.  The following table compares the commercial and industrial growth of BLOS products to previous shifts in medical history due to the recognition of a new disease.  Detection and measurement methods begin the wave.  Finally, with widespread knowledge of BLOS, it will be recognized as a Black Swan for Health Care.

BLOS spurs economic growth in healthcare and beyond
Short list of New Products based on BLOS Management

Skin In The Game

Taleb will be happy to know that I have “skin in the game.”  In addition to a couple of published research articles, I have a pending patent for a new method to measure BLOS.  My company, HemaGnosis, is developing this new BLOS# method.  All proceeds from my eBook sale and items sold in the BLOS World Store will be used to support BLOS Research.

 

Click on the image below to download our Free Report on the Best Vitamin C Supplement for fighting Oxidative Stress.

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Best Antioxidant Supplements For Your Pet

Which antioxidant supplements are the best for your pets?

If Blood Oxidative Stress or BLOS impacts your pet’s health, then an antioxidant supplement may help reduce BLOS and improve your pet’s health.  BLOS has been suggested as a cause of Obesity and Diabetes, since it can inhibit glucose transport and fat metabolism.  There is a growing problem of obesity and diabetes in our pets.  Are we feeding our pets too much or is it something in the food causing BLOS?  Beyond pet food, we may be able help our pets by providing an effective antioxidant supplement.  Could antioxidant supplements consisting of effective antioxidants and designed for time-release help your pet?  We reviewed the scientific research and provided a short list of the Best Antioxidant Supplements for your Pet.

Blood Oxidative Stress May Harm Your Pet’s Health

Let’s learn more about BLOS.  Although there are two distinct sources of Oxidative Stress, Blood Oxidative Stress is the primary source of Oxidative Stress in humans.  This is due to the high prevalence (estimated 2/3 of adult Americans) and danger of its continuous production of reactive oxygen species (ROS).  Inorganic sulfur based food additives and preservatives in the Western Diet may cause BLOS.  Many commercial pet foods use the same additives and preservatives, which may also cause BLOS in our furry friends.  Consequently, a Western Pet Food Diet may impact our pets in a similar way as the Western Diet impacts our health.  An ambitious veterinarian could try to evaluate pet foods using an available Urine Oxidative Stress kit.  Good luck collecting that urine sample!

Best Antioxidant Supplements For Your Pet May Improve Their Health

Here is a recent study from the University of Illinois at Urbana-Champaign (my Alma Mater!) describing the benefit of an antioxidant supplement loaded with Taurine and Vitamin E that helps maintain their levels in active dogs.  It is well known that active dogs like the ones in this study generate high levels of Oxidative Stress (reactive oxygen species or ROS).   Consequently, this activity can deplete critical compounds for maintaining health, such as antioxidants and essential amino acids.  Vitamin E is a great antioxidant that is effective in reducing Oxidative Stress in humans.  Does it surprise you that Vitamin E is also effective in reducing Oxidative Stress in active dogs?  Taurine is an essential amino acid that is also helpful in maintaining your pet’s circulatory system.  Here is a list of the Best Antioxidant Supplements for your pet that may help manage Oxidative Stress.

VetriScience Laboratories – Cardio Strength, Cardiovascular and Circulatory Support Supplement for Dogs and Cats

This supplement has both Vitamin E, Taurine, and more!

Nutrition Strength Cardio Support for Dogs Plus Antioxidant and Vitamin E for a Healthy and Strong Heart

This supplement is for dogs and also contains high levels of both Vitamin E and Taurine!

Excel 8in1 Daily Time Release Multi-Vitamin for Dogs 

This supplement is for older dogs and features antioxidants and vitamins to help your pooch manage oxidative stress.  If only they added Taurine to the formulation….some day.

HemaGnosis focused on the fight against Oxidative Stress!

Our BLOS World Store has the best products to help you and your pet manage Oxidative Stress.  We’ve recently added a number of BLOS Hack Kits that feature my new eBook.

Infographic describing the components of the BLOS Hack Kits

We’ll keep providing useful information about fitness tips, food, and supplements to help you (and your favorite furry friend!) with your fight against Oxidative Stress.  Management of Oxidative Stress is important, because it may cause multiple human health problems including: Obesity, Type 2 Diabetes, Hypertension, and a greater risk for Cancer.  As always, read our Disclaimer and check with your veterinarian before giving your pet a new supplement.  Learn more about Blood Oxidative Stress or BLOS at www.hemagnosis.com.

Click on the image below to download our Free Report on the Best Vitamin C Supplement for fighting Oxidative Stress.

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Oxidative Stress Prevention Tips Improve Health

Can Lifestyle Choices Reduce Oxidative Stress?

Oxidative Stress is the major healthcare problem plaguing the United States, Europe, and other countries that adopted the Western Diet.  The major source of Oxidative Stress is from the blood, which presents major problems for management or prevention to improve health.  First, Blood Oxidative Stress or BLOS cannot be measured due to the lack of a proper method.  Second, BLOS is continuous (24/7), while General Oxidative Stress is temporary.  High, variable levels of Oxidative Stress depletes your body’s own antioxidants, whether from diet or the body.  Poor fitness in adult Americans also contributes to poor BLOS management due to minimal endogenous antioxidant production.  Endogenous means that your own body makes it.  Oxidative Stress prevention could be the key to improving health.

Effective Fitness to Fight Oxidative Stress and Improve Health

My previous post on the role of fitness focused on the benefit of short periods of intense exercise.  This approach prompts your body to generate nitric oxide (NO), which helps reduce hypertension.  There are reports that the increased production of NO from exercise also stimulates the production of plasma sulfide, which also reduces hypertension.  I updated my map of BLOS management to include Fitness (blue arrow).  The combination of both dietary changes and improved fitness may help you fight Oxidative Stress for better health.

Effective Diet and Fitness helps Oxidative Stress Prevention
Combination of Dietary and Fitness Changes for Oxidative Stress Prevention for Improved Health

Oxidative Stress Prevention Could Improve Your Health & Save Money

Blood Oxidative Stress or BLOS is thought to be the major source of multiple health problems, which costs adult Americans an average of $4,800 per year.  Most of this cost is out-of-pocket money due to the high deductibles of most health insurance plans.  A modest investment in fitness equipment and dietary changes could save you money.

BLOS World Store Offers Great Products To Help You Now

For men or women, a good pair of walking shoes and a heart rate monitor will cost about $110, but only $37/year for a 3 year life.  Add a good time-release antioxidant supplement $112/year) and switch to food items rich in anti-oxidants ($300/year) for a total cost of $412/year for dietary changes.  MitoQ may be the ultimate antioxidant supplement, but it will cost you about $720/year.  The total investment without MitoQ is $449/year plus your time and sweat!  We combined these great products in a variety of BLOS Hack Kits.  Start with my eBook and the MDA Urine Oxidative Stress Kit to evaluate your current lifestyle choices.  Click on the figure below and you’ll go directly to the BLOS World Store.

Infographic describing the components of the BLOS Hack KitsBLOS Management is a Good Investment in You!

You could manage your BLOS and improve your health for large healthcare cost savings without breaking the bank.  Just review the figure below for some ideas on the potential health care cost savings.

Manage BLOS and Reduce Healthcare Costs
Modest Investment in Dietary Changes and Fitness Equipment could manage BLOS for Improved Health and Lower Healthcare costs.

HemaGnosis focused on Oxidative Stress Prevention!

Our BLOS World Store offers the best selection of fitness equipment, food items, and antioxidant supplements.  We provide useful information to help you with Oxidative Stress Prevention.  BLOS may cause multiple human health problems including: Obesity, Type 2 Diabetes, Hypertension, and a greater risk for Cancer.  Learn more about Blood Oxidative Stress or BLOS at www.hemagnosis.com.

Click on the image below to download our Free Report on the Best Vitamin C Supplement for fighting Oxidative Stress.

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What Are The Signs Of Oxidative Stress From Blood?

Is BLOS an Asymptomatic Disease?

The signs of oxidative stress from blood take years to fully develop, but early diagnosis may prevent many health problems.  The traditional approach to disease diagnosis is through the observation of one or more symptoms.  Rapid, accurate diagnosis is the key to treating symptomatic diseases.  Diseases that take years or decades to manifest as symptoms are Asymptomatic and rely on the underlying pathology for diagnosis.  Two examples of Asymptomatic Diseases are Alzheimer’s and Cardiovascular Diseases.  A recent news article describes how the Research Community redefined Alzheimer’s Disease as an Asymptomatic Disease.  In turn, this new definition will lead the development of new drugs for treating the underlying pathology before symptoms develop.  Blood Oxidative Stress or BLOS is another Asymptomatic Disease that demands more attention from the medical research community and public health officials.

Blood Oxidative Stress (BLOS)

Oxidative Stress receives lots of attention from medical researchers with new theories suggesting it causes multiple health problems including an increased risk of cancer.  There at least two sources of Oxidative Stress and Blood Oxidative Stress or BLOS may be the dominant source.  BLOS may be the true underlying cause of several diseases.  In fact, the underlying cause of Cardiovascular Disease may be BLOS, since it provides a mechanistic model for atherosclerosis that does not depend on a genetic mutation.

Learning about Signs of Oxidative Stress from Blood may prevent long-term development of serious health problems.
BLOS is another Asymptomatic Disease like Alzheimer’s and Cardiovascular Diseases. Learn about the signs of oxidative stress from blood in order to prevent long term health problems from developing.

Signs of Oxidative Stress from Blood

Like Cardiovascular Disease and Alzheimer’s Disease, medical research can evaluate the underlying pathology of BLOS.  The presence of a high percentage of ROS+ blood cells and low plasma sulfide concentration are the signs of oxidative stress from blood.  Currently, the gold standard for measuring BLOS is an expensive method involving flow cytometry.  HemaGnosis will develop an inexpensive method for measuring BLOS that will be critical for early detection and management of BLOS.  You can support BLOS Research efforts by purchasing items through the BLOS World Store.

Click on the image below to download our Free Report on the Best Vitamin C Supplement for fighting Oxidative Stress.

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Blood Oxidative Stress Tests To Guide Lifestyle Choices

Review of Current and Future Tests for Measuring Oxidative Stress

Here is a list of the Top Oxidative Stress Tests available for evaluating your lifestyle choices.  These tests measure the level of different biomolecules that provide evidence of Oxidative Stress.  Oxidative Stress is thought to the the primary cause of multiple health problems.  Blood Oxidative Stress or BLOS is thought to be the main source of Oxidative Stress in humans.  If we have any hope in managing BLOS, then we need a way to measure its level.

Oxidative Stress Tests Evaluate Breath, Urine, or Blood

In the following figure, three different samples, breath, urine, and blood, are available to measure Oxidative Stress.  For breath and blood, two tests measure Reactive Oxygen Species or ROS.  In contrast, the urine test measures the reaction end products of ROS and biomolecules.

Samples available for testing Oxidative Stress

 

Consider these Oxidative Stress Tests to evaluate whether your new diet or antioxidant supplements reduces BLOS with an improvement in your health.

F2-IsoPs/oxLDL/MPO

The F2-IsoPs blood test measures the level of F2-isoprotanes, which are an end product of Oxidative Stress.  The oxLDL blood test is the current Gold Standard of evaluating Oxidative Stress.  This test measures the oxidation of Arachidonic Acid, an end product of Oxidative Stress.  The MPO blood test evaluates the level of the enzyme, Myeloperoxidase (MPO) released by the White Blood Cells.  The TOTAL COST OF ALL 3 TESTS IS $213.

Urine Free Radical Test Strips

Blue Diamonds offer an inexpensive urine test strip that measures the Malondialdehyde or MDA, which is a byproduct of Oxidative Stress.  Use this Oxidative Stress test now to evaluate your lifestyle choices.

OxiChek

This is a breath test that is available through your physician with an estimated to cost $45.

BLOS#

This new blood test is currently in development by HemaGnosis.  The BLOS# test measures the causative agent of Oxidative Stress, the abundance of the ROS+ blood cells.  The BLOS# test has the potential to be a Disease Diagnostic, while the other three Oxidative Stress tests will only be LifeStyle Choice Tests.  Health Insurance companies do not pay for LifeStyle tests.

Comparison of Oxidative Stress Tests 2018
Tests for Measuring Oxidative Stress 2018

Oxidative Stress Tests are Key To Evaluate Lifestyle Changes

If you decide to change your diet or start taking antioxidant supplements to manage your Oxidative Stress, then consider using these tests to evaluate your changes.  As always, consult with your physician before making any changes to your diet or exercise regime (see our Disclaimer).  If you have an interest in learning how lifestyle choices may lower your Oxidative Stress, then consider purchasing my new eBook.

HemaGnosis focused on the fight against Oxidative Stress!

Our BLOS World Store offers many healthy food items and antioxidant supplements.  A wide collection of Oxidative Stress Hack Kits are now available to help you.

Infographic describing the components of the BLOS Hack Kits

We will provide useful information to help you with your fight against Oxidative Stress.  Blood Oxidative Stress is thought to cause multiple human health problems including: Obesity, Type 2 Diabetes, Hypertension, and a greater risk for Cancer.  Learn more about Blood Oxidative Stress or BLOS at www.hemagnosis.com.

Click on the image below to download our Free Report on the Best Vitamin C Supplement for fighting Oxidative Stress.

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What is Oxidative Stress? It’s from the blood!

Blood Oxidative Stress is an Expensive Health Care Problem

What is Oxidative Stress?  Let’s review the two sources of Oxidative Stress and determine which source is more important.  General Oxidative Stress is thought to be the only source of Oxidative Stress.  However, Blood can also generate Oxidative Stress, which is also known as BLOS.  This post provides information about why BLOS is more important compared to General Oxidative Stress.

Second source of Oxidative Stress may be important to your health
Blood Oxidative Stress may be the primary source of Oxidative Stress causing multiple health problems.

General Oxidative Stress

The mechanistic model of General Oxidative Stress starts with an elevated rate of metabolism that results in mitochondrial dysfunction.  In turn, this leads to an increased production of reactive oxygen species (ROS).   Medical researchers observe General Oxidative Stress in tissue cultures, but it is difficult to observe in the human body.  How many biopsies are needed to identify the tissues sources of General Oxidative Stress?  Instead, medical researchers rely on diagnostic methods that evaluate ROS or oxidation end products in blood, urine, or breath.

General Oxidative Stress and ROS

ROS includes O2 (superoxide radical), OH (hydroxyl radical) and H2O2 (hydrogen peroxide). The ROS molecules diffuse into the bloodstream and react with biomolecules throughout the body.  The end products of these ROS reactions can be measured in blood, urine, and breath.  The general consensus on the primary cause of General Oxidative Stress is the high caloric content of the Western Diet.  Excessive alcohol consumption is a special case of General Oxidative Stress.  It causes short periods of ROS generation in the liver and other organs.  Short periods of ROS generation is a primary characteristic of General Oxidative Stress.  It is due to the reliance on excessive substrate availability necessary for the elevated rate of metabolism.  A second source of Oxidative Stress is from blood cells, which received little attention from medical researchers or the general public.

Blood Oxidative Stress

White blood cells and platelets can generate high rates of ROS, which is alarming when the patient does not have an infection.  In 2008, Walter Paulus’ research group reported on ROS+ blood cells in both healthy (non-hospitalized) and congestive heart failure (CHF) patients.  Here is the link for the Abstract of the research article describing Blood Oxidative Stress or BLOS: https://www.ncbi.nlm.nih.gov/pubmed/18957960  This article provides interesting BLOS data and I will focus on the most important findings, which escaped the attention of the researchers.  The research community missed it, but this is understandable when you consider that there are over 200,000 research articles about Oxidative Stress.  The Paulus’ paper is the proverbial “needle in the haystack” for Oxidative Stress.

Mitochondrial ROS

BLOS was reported in two different ways (Cytoplasmic vs. Mitochondrial) in two different blood samples (Arterial vs. Venous) from two different groups (“healthy” vs. CHF patients).  The level of BLOS (or BLOS#) refers to the percent of ROS+ blood cells (i.e., generate high levels of ROS).  The most accurate measurement of BLOS# is the Mitochondrial measurement for the Arterial sample.  Consequently, the Venous samples will always be the same or slightly greater compared to the Arterial measurement.  This is due to the ROS transfer from a source (ROS+ blood cells nearby or General Oxidative Stress).

BLOS is primary source of Oxidative Stress
ROS+ blood cells generate blood oxidative stress (BLOS), the primary source of Oxidative Stress

Here is a table that brings together the most interesting data in the paper.

Comparison of % of Blood Cells with Mitochondrial Oxidative Stress for Healthy vs. CHF patients

So, What is Oxidative Stress?

Let’s start with the easier set of data for the CHF patients.  It is clear that the BLOS# for the Arterial and Venous samples are identical.  I interpret this as little contribution from General Oxidative Stress (1.5% of the Total Oxidative Stress or 1/65).  Otherwise, the BLOS# for the Venous sample would be much higher.  The Venous sample could have false positives or blood cells with high levels of ROS transferred from true ROS+ cells.  Granted, there are fewer ROS- blood cells available (36%) for ROS to enter.  However, the high level of BLOS should also generate even more ROS available in the plasma to diffuse into the ROS- blood cells.  To be complete, small vessel disease (SVD) could also increase the BLOS# for the Venous sample.  SVD would increase the time available within the capillary network for ROS to transfer from a ROS+ blood cell to a ROS- blood cells.  This does not appear to be the case for the CHF patients.  Now let’s review the data for the “healthy” people.

Non-Hospitalized Just Means Non-Hospitalized

The group of “healthy” people have a much lower BLOS# for both Arterial and Venous samples compared to the group of CHF patients.  Now, non-hospitalized doesn’t mean healthy.  Certainly, one can be unhealthy and non-hospitalized.  There is a clear difference between the Venous and Arterial BLOS# averages.  The final row in the table provides the difference between the two values.  It suggests that 30% (5/17) of the Total Oxidative Stress may be due to General Oxidative Stress or SVD or a combination of the two.  Here is my explanation for the higher estimate.

Not All BLOS is Equal

If you examine the BLOS# values for Cytoplasmic Oxidative Stress, there is a much greater difference in the healthy group.  The simplest explanation is that the rate of ROS generation from the ROS+ blood cells is much greater in the healthy group versus the CHF patients.  (There is a figure in the paper not shown here that provides this evidence)  Perhaps, the healthy group are more (metabolically) active compared to the CHF patients?  This means that General Oxidative Stress is probably much lower than 30%.  The CHF group suggests 1.5%, which is closer to 5-10% of the Total Oxidative Stress.

General Oxidative Stress Is Not Important

Another possible factor could be that General Oxidative Stress may not be active at the time of sampling.  This explanation also suggests that General Oxidative Stress is not as important compared to BLOS.  BLOS is continuous, while General Oxidative Stress is temporal (i.e., few hours).  Finally, more research and a robust diagnostic tool to measure BLOS are imperative.

CALCULATIONS

Here is more details on the BLOS# calculation.

STEP 1

In Step 1, I used Figure 5 from the publication cited to estimate the number of ROS+ blood cells for each pair of samples collected from the six volunteers.  For Volunteer A, I estimated the Venous Count (blue dashed line) at 275 and the Arterial Count (red dashed line) at 150.  I recorded the pair of values for each Volunteer in my Excel workbook.

Step 1 of 2 for calculating the contribution of both sources of Oxidative Stress

STEP 2

In Step 2, I used a conversion factor from the publication where BLOS# of 17 is equivalent to 126 ROS+ blood cells.  I applied this conversion factor (count x conversion factor) to each count and computed a BLOS# for the Venous and Arterial counts for each Volunteer (lower table).  The difference (Venous BLOS# – Arterial BLOS#) is the contribution of General Oxidative Stress to the volunteer’s Total Oxidative Stress.  Keep in mind that Small Vessel Disease (SVD) could also play a role.  SVD is probably doubtful for all of the non-hospitalized volunteers except one that reported Hypertension.  Which volunteer has Hypertension?  We will never know, but my money is on Volunteer A (the highest Venous BLOS#).

Step 2 of 2 for Calculating the Contribution of Both Sources of Oxidative Stress

Healthy vs. Non-Hospitalized

Remember that this data corresponds to the “Healthy” group, but the description of “non-hospitalized” is more accurate.  From this group, we learn that the minimum BLOS# is 5.4% (Volunteer D), which may provide guidance on a BLOS# that actually corresponds to “healthy”.  However, Volunteer D also has a GOS# (General Oxidative Stress #) of 8.8%.  Is this person healthy?

Is there a Healthy Level of BLOS?

What else can we learn from this analysis?  The range of BLOS# is 5.4%-20.2%, while the range for the GOS# is 0 (-2.0%) to 16.9%.  A comparison of the Averages of the BLOS# and GOS# suggests that BLOS is the more important source of Oxidative Stress.  It also appears that half of this group do not suffer from any significant General Oxidative Stress.

Comparison of Two Sources of Oxidative Stress

The following table provides a summary of the main characteristics of the two sources of Oxidative Stress.  General Oxidative Stress is still undefined with respect to the primary cause, tissue location, and duration.  It is doubtful that it will ever be defined.  In contrast, Blood Oxidative Stress is defined (ROS+ blood cells) and appears to be the dominant source of Oxidative Stress.  One theory proposes that diet is the origin of Blood Oxidative Stress.  Certainly, BLOS# measurements during the course of dietary studies will test this hypothesis.

Big differences in two sources of Oxidative Stress answer the question of What is Oxidative Stress.
Comparison of the two sources of Oxidative Stress used to answer the question of “What is Oxidative Stress?”

Take Home Message

The data reviewed in the Post suggests that BLOS is the primary source (90% or more) of Oxidative Stress and demands more research.  With the lowest reported BLOS level of 10%, it is unclear whether this is a healthy value.  The only way to study General Oxidative Stress is to have a method for managing BLOS.  Two different sources of Oxidative Stress causes confusion in medical research regarding dietary advice, fitness tips, and pharmaceutical research.  I will  post more information on these topics in the near future.

 

HemaGnosis focused on the fight against Oxidative Stress!

Our BLOS World Store offers quality products to help you manage Oxidative Stress.  My new eBook provides a simple strategy to Hack Oxidative Stress using many of the products offered in our BLOS World Store.

Infographic describing the components of the BLOS Hack Kits

We will provide useful information about food to help you with your fight against Blood Oxidative Stress or BLOS.  Most noteworthy, Blood Oxidative Stress is thought to cause multiple human health problems including: Obesity, Type 2 Diabetes, Hypertension, and a greater risk for Cancer.  So, it is important for you to learn as much about Blood Oxidative Stress or BLOS by reviewing the information at my website: www.hemagnosis.com.  If you enjoy this post, then you can subscribe to my blog.

Click on the image below to download our Free Report on the Best Vitamin C Supplement for fighting Oxidative Stress.

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