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Could the high rate of failed clinical trials for new drugs be due to Long-Term, Elevated BLOS?

Elevated BLOS is very common (2/3 of Adult Americans) and causes elevated levels of ROS, which may be oxidizing the experimental drug into an inactive form or a lethal form.  Why not manage BLOS in Phase 2 patients for a better evaluation of the experimental drug?

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Medical researchers may want to go back and check the health state of the patients in a failed Phase 2 clinical trial.